[NUC] Will ROG NUC work with only one SODIMM installed in a single channel configuration?

Yes. However, the system may experience reduced performance running in single channel as compared to a dual channel configuration which contains two SODIMMS with total equivalent capacity and speed. e. g. (1x 16GB SODIMM) in a single slot vs. (2x 8GB SODIMM) one in each memory slot.