ASUS ExpertCenter D5 SFF (D501SER)
Powerful, expandable and always reliable


  • Windows 11 Pro - ASUS recommends Windows 11 Pro for business
  • Up to Intel Core i7 14th gen processor
  • Up to NVIDIA GeForce GT 1030 graphics
  • 8.6L compact and tool-free chassis with removable cage for maximum expandability
  • Durability-tested to MIL-STD 810H military-grade standard and ASUS in-house testing
  • Extensive I/O ports to support all your connectivity needs

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A right 45-degree angle view of ASUS ExpertCenter D5 SFF D500SER

Outstanding Value for business at any sizes

Engineered for the specific demands of small business, ASUS ExpertCenter D5 SFF is a desktop with AI-driven Microsoft Copilot that delivers powerful, trustworthy and expandable performance. Its modern, ultra-compact, and flexible design caters to diverse workspaces and usage scenarios — and allows businesses to take advantage of ASUS-exclusive small-business support services to minimize both downtime and total cost of ownership and maximize the value of your investment.
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Secure manageability
ExpertCenter D5 SFF prioritizes security through TPM 2.01, providing advanced protection with two options: a software-based firmware TPM solution running on the CPU; or discrete TPM (dTPM), a dedicated chip offering an additional layer of defense against sophisticated threats.
An expandability icon.
Efficient expandability
The perfect balance of performance and size with remarkable expandability that provides space for essential hardware to support diverse productivity needs.
A tool-free icon.
Tool-free chassis
The redesigned tool-free chassis makes it easier to remove components by hand, simplifying routine servicing and making future upgrades a breeze.
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Ultimate reliability
Built with industry-leading ASUS motherboards and tested to stringent ASUS and MIL-STD 810H US military standards2, minimizing risk of damage and maximizing longevity.

Exceptional performance, whatever the task

To make light work of all your business tasks, ExpertCenter D5 SFF is powered by the latest Intel® Core™ 14th gen processors with up to 64 GB DDR5 RAM. An NVIDIA® discrete GPU is an option for those requiring advanced graphics performance for demanding visual tasks.
Windows 11 Pro
 
14th Gen
Intel® CPU
Up to
64 GB
DDR5 RAM
Up to
2 TB + 2 TB
HDD + SSD3

Microsoft Copilot

AI-powered Microsoft Copilot4 in Windows with commercial data protection is your Al assistant at work. Supercharge your productivity and achieve more with less time and effort using Copilot AI. Experience your everyday Al companion now with the dedicated Copilot key. Just one click for endless exploration.

Maximize your workspace

ExpertCenter D5 SFF desktop with AI-enhanced Microsoft Copilot is up to 10%5 smaller than previous-generation models, making it even more compact — help to maximize your office workspace. And its sleek and elegant design gives your business a truly professional look — ready to work in style.
An ExpertCenter D5 SFF is placed on the table with a bigger translucent, virtual desktop outline on top, and a pen holder on the right.

AI noise-canceling audio technology for business

To level up professional conferencing, ExpertCenter D5 SFF desktop has two-way AI noise-canceling technology6 that employs sophisticated machine-learning techniques. The technology includes both an upstream function to filter noise around the speaker, and a downstream function to eliminate noise from the person at the other end of the conversation. Try the demo to experience the amazing difference that ASUS two-way AI noise-canceling technology can make.
Turn on your device’s audio and press play to experience AI noise-canceling technology.
Committed to creating a sustainable future, ASUS ensures all its products are compliant with environmental requirements at all stages of their product life cycles. The ExpertCenter D5 SFF is registered as EPEAT Gold7, and is also ENERGY STAR® 8.0-certified to reduce long-term costs with its energy-efficient design.
Expert-series PCs are solidly-built and tested to the most demanding industry requirements, including MIL-STD 810H US military standards and stringent ASUS in-house testing. The inevitable minor shocks and everyday workplace accidents won’t jeopardize your precious data2.

Ready for the business world

A full array of I/O ports is ready to connect ExpertCenter D5 SFF to a wide range of business peripherals. It has four front-mounted USB ports for quick and easy access and flexible serial port on chassis leave more PCI Express® slots available for additional upgrades and an optional SD card reader for easy transactions, data transfer, or other business-related tasks.
Upgrade your business with agile solutions tailored to your needs.
Learn more
  1. Actual product appearances may vary, and the images displayed are for illustrative purposes only; please refer to product descriptions for accurate information.
  1. Trusted Platform Module (TPM) is optional.
  2. The testing regime includes the requirements of both military-grade standards and ASUS quality tests and varies depending on device. MIL-STD-810H testing is conducted on selected ASUS products only. Note that the MIL-STD-810H testing helps to ensure the quality of ASUS products but does not indicate a particular fitness for military use. The test is performed under laboratory conditions. Any damage caused by attempts to replicate these test conditions would be considered accidental and would not be covered by the standard ASUS warranty. Additional coverage is available with ASUS Premium Care.
  3. Please note that ExpertCenter D5 SFF includes up to 2 x 1 TB M.2 SSD, and up to 1 x 2 TB 3.5” HDD, for total storage capacity of up to 4 TB.
  4. a) Screen simulated, subject to change. Feature availability and rollout timing varies by market and device.
    b) Copilot in Windows (in preview) is rolling out gradually within the latest update to Windows 11 in select global markets. Timing of availability varies by device and market. Learn more: https://www.microsoft.com/en-us/windows/copilot-ai-features?r=1#faq
    c) Copilot with commercial data protection requires Microsoft 365 E3, E5, Business Standard, Business Premium or A3 or A5 for faculty, or accessed using Microsoft Entra ID.
  5. Based on ASUS internal testing and measurements. Unless otherwise stated, all performance claims are based on theoretical performance. Actual figures may vary in real-world situations.
  6. AI noise-canceling audio technology only applies when connected to external mics.
  7. D501SERS refers to the SKUs of D501SER with Energy Star and EPEAT certifications.
  8. ASUS Endpoint Management Service (AEMS) and ASUS Pre-Deployment Service (APDS) are optional, and their availability varies according to country. Please check with your local ASUS retailer for details.
  9. ASUS secured the #1 spot for motherboard market share as of 2017, with DigiTimes reporting that the Taiwanese PC component giant owns 45% of the motherboard market.
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